Isekai anime are inescapable. Without fail, every season includes a few shows that send their protagonists to alternate worlds filled with magic, wonder, danger, elves, and dungeons. Oftentimes, these average guys (or gals, rarely) gain incredible abilities that allow them to lead carefree lives defined by wealth, freedom, power, and harems. Occasionally, they find themselves stuck in a dark fantasy realm where one false move could spell their end. Love or hate them, these series are popular and are here to stay.
As overexposed as this concept has become, isekai anime have an undeniable charm to them, even the so-called “trashy” ones. Even at its worst, this theme can still work as a tension-free escape from reality that asks nothing from viewers. Conversely, the best isekai anime are fantastic works of art that offer adventure, comedy, action, world-building, character growth, and stellar animation. To simplify the rummaging process, let’s highlight isekai’s greatest animated efforts.
Updated on October 16, 2025 by Mark Sammut: The Fall 2025 season has been great, and that includes isekai. Let’s highlight two new shows that every fan of the theme should check out.
Fall 2025’s Best New Isekai Anime
The Fall 2025 season is underway, and it has been pretty good so far. Shows like Spy x Family and My Hero Academia are hogging most of the limelight, but the season also has plenty of exciting isekai anime. If you are remotely into slow-life goodness, Campfire Cooking in Another World with My Absurd Skill Season 2 should be a must-watch for you. It is one of the season’s best slice of life anime, regardless of theme. Just excellent stuff.
In terms of new isekai anime, Fall 2025 has one of the strongest lineups in a long time, with multiple candidates that could realistically land among the greatest shows ever. Let’s highlight the two best new series. That said, you need to have a fondness for overpowered MCs.
A Wild Last Boss Appeared!
OK, this isekai anime delivers exactly the type of experience suggested by its title. Basically, Overlord, but with a female character and less interested in kingdom building (for now, at least). Lufas is a super-powerful gaming character who was finally defeated in a game; however, her creator reincarnates as her 200 years after she died in the game. He/She quickly adapts to the situation and realizes that she is far more powerful than pretty much everyone else, allowing her to “slaughter” rather than just defeat enemies.
A Wild Last Boss Appeared is OP MC comfort food. So far, the series has done almost nothing original, although it is refreshing to see a female avatar with this type of moveset. Still, the action is good and surprisingly vicious, while Lufas is likable enough as the “villainess.” She is sidelined by some interesting characters as well.
My Status as an Assassin Obviously Exceeds the Hero’s
Another Fall 2025 show with a powerful protagonist, My Status as an Assassin Obviously Exceeds the Hero’s, features another popular trope: the full-class summon. Oda Akira is just one of many students summoned to a new world to help save it, and he realizes that his stats as an assassin are much higher than the hero’s. While most of the students go along with their summoner’s requests and believe them to be their allies, Akira does not, and his suspicions quickly prove to be well-founded.
While still too early to say if this story will amount to anything more than enjoyable angst, My Status as an Assassin Obviously Exceeds the Hero’s has been really entertaining so far, with good action sequences, a solid protagonist, and good use of secondary characters who are starting to develop their own separate stories.
Cautious Hero: The Hero Is Overpowered But Overly Cautious
Isekai loves an overpowered protagonist who can blast through skyscraper-sized enemies while barely breaking a sweat. When the goddess Ristarte summons Seiya to help her save a world on the brink of annihilation, she gets a hero who is only willing to dive into threatening situations when victory is 100% assured. Basically, this means a lot of training and taking no chances during battles.
Cautious Hero: The Hero Is Overpowered but Overly Cautious is a mostly lighthearted adventure built upon the love/hate dynamic between Seiya and Ristarte. Driven primarily by humor, the anime uses its protagonist’s unique mindset to produce comedy gold.
No Longer Allowed in Another World
While looking to end his life with his lover, Osamu Dazai is hit by a truck and wakes up in a fantasy world where he is quickly informed about his status as an Other Worlder with heroic ambitions. However, the Japanese author is not particularly pleased with this turn of events, and his goal is to find his partner and end his love. Fortunately, he quickly becomes surrounded by girls who would rather keep him around.
A dark comedy with a charming protagonist, No Longer Allowed in Another World is a clever isekai parody that includes a few subversions of the theme’s tropes and cliches. More importantly, Dazai is just an enigmatic lead who feels very fresh compared to most modern isekai MCs. As with all comedies, the humor does not always hit the mark, but enough jokes land to make up for the misses.
While always comedic, No Longer Allowed in Another World has some surprisingly poignant episodes, particularly during the second half of its run.
Ishura
As isekai anime have a habit of playing things too safe, a show that is willing to take risks should be commended. However, just because something is different does not automatically make it good, and Ishura does not leave a great first impression. In a world with many Visitors and other superpowered entities, city-destroying conflicts are always on the horizon, especially since the True Demon King’s death left a power vacuum.
Ishura is structured unusually for not only an isekai but also anime in general. Rather than focusing on a single character, the show dedicates the first five episodes to introducing different OP archetypes, dedicating about 10 minutes to each. As these stories are only loosely connected, the first half of season one is confusing and hard to follow. However, things come together nicely in the second half, when all these characters clash in a war between two empires.
Although not devoid of world-building or political intrigue, Ishura’s selling point is its fights pitting overpowered characters against each other, and the roster is diverse and absurd. Season 2 is a bit more focused than its predecessor, but it mostly exists for the same reason.
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